Pancreatic carcinoma originates in the tissue of the pancreas – an organ that is vital for digestive and metabolic processes. Surgical removal of pancreatic cancer is rarely possible because it spreads rapidly and is very difficult to detect in the early stages. Symptoms are scarcely noticeable until the cancer has spread. The symptoms consist of upper abdominal pain, weight loss, loss of appetite, and yellowing of the eyes and skin. Pancreatic cancer can be treated with surgery (if discovered early enough), radiation therapy, chemotherapy, and targeted therapy.